Kosheeka : Primary Cells for Research

  The goal of every drug discovery is to develop safe and effective medications. To achieve this crucial goal, a key step involves studying the metabolism of drugs in order to understand their potential toxicity and effectiveness. Even before we start preclinical trials on human primary cells or animals, we need to test the drugs in vitro to ensure their safety and efficacy. One major step forward is the use of mouse liver subcellular fractions. Why are these fractions important? New drugs need to be safe and effective. Part of this safety check involves understanding how our bodies metabolize the drug. These mouse hepatocyte S9 fractions mimic the human liver's metabolic machinery, helping researchers predict how a drug will be processed in the body. We have three types of fractions, namely S9, microsome, and cytosol, that can offer a significant understanding to improve drug discovery. Think of these fractions as specialized teams within the liver cell, each with a specific role ...

               The tiny powerhouses within us—CELLS—play a starring role in the exciting world of drug discovery! But how do researchers utilize different cell types to develop new treatments? It all starts with the cell selection dilemma! Wait, let me explain what I meant! Consider our body as a vast library, but instead of books, it's filled with millions of cell types, each with unique functions. If you have to pick one book and try to alleviate what is plaguing it, it will be challenging. That is the same dilemma researchers face: choosing the right "cell-ebrity" for their specific research needs. There are three main categories of the cells that are present: Immortalized Cell Lines: These are the cells that can be grown indefinitely, offering a reliable source for various experiments. However, they do not always perfectly reflect what happens inside the body. Dissociated Tumor Cells (DTCs): Directly extracted from tumors, these cells offer ...