The Rise of Mesenchymal Stem Cells in Oncology

 Cancer researchers can improve and hone cell and gene therapy choices to provide individualised medical treatments through the immunomodulatory properties of mesenchymal stem cells. Cancer medicine and therapy developers can alter the functioning of the cells to promote cancer suppression by utilising mesenchymal stem cells' capacity to modify the tumour microenvironment. Mesenchymal stem cells, for instance, present a route to deliver anti-cancer medications to tumour locations due to their propensity to move to tumours. Additionally, researchers can control mesenchymal stem cells via antibody treatment and modify the angiogenesis process, which cancers depend on to thrive.



Immunomodulatory effects of MSCs

The immunomodulatory characteristics of MSCs offer researchers a powerful weapon against cancer, serving as the foundation for immunotherapy. The development of immune system cells such macrophages, dendritic cells, T cells, B cells, and natural killer cells (NK cells), which can control and suppress malignant cells, from mesenchymal stem cells is a possibility. 


Mesenchymal stem cells can stimulate T cells, making them useful in the development of CAR-T cell therapy, potentially a more successful type of cell therapy for cancer. The capacity of mesenchymal stem cells to preferentially locate and move to tumour areas offers the possibility of enhancing the activity of CAR-T cells intended to eradicate cancer via modified T cells.


The Role of Gene and Cell Therapy

Mesenchymal stem cells can be successfully used in cancer gene therapies in conjunction with cell therapies. Genes can be delivered by MSCs like how medications can be sent by them to tumour sites. Mesenchymal stem cells can be given genetic material that will change the way that living tumour cells behave or behave differently, and they can then deliver this therapy by recognising and migrating to tumour sites. Additionally, MSCs can be genetically altered to produce particular proteins that are designed to combat cancer.


It is also possible to use the interaction between mesenchymal stem cells and other cells in the tumour microenvironment, specifically cancer stem cells, to treat cancer. Hindering the two types of cells' ability to communicate with one another may help to reduce the number of cancer stem cells, reduce medication resistance in tumours, and minimise the capacity of cancers to metastasise and/or grow. Exosomes, a kind of extracellular vesicle that MSCs and CSCs use to communicate, can be employed by researchers to destroy cancer stem cells.


Finally, treating cancer with mesenchymal stem cells is not limited to preventing it. The potential of mesenchymal stem cells to create tissue to repair tumour-damaged bones can also be used in regenerative medicine.


If you are a researcher working in academia or industry and looking for Mesenchymal stem cells and cancer cells for your research, get in touch with us at info@kosheeka.com or call/WhatsApp at +91-9654321400

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